Navigating the terrifying depths of the Umbrella Corporation's underground laboratory is one of the final challenges in the Resident Evil 2 remake. When embarking on the B Scenario, also known as the 2nd Run, players will notice that several puzzle solutions have been altered from their original placements. Knowing these adjusted combinations beforehand can save you valuable time and keep you safe from the terrifying creatures roaming the greenhouse.

The Greenhouse Hatch Terminal Solution

To begin exploring the lower levels of the laboratory, you must first unlock the security hatch located within the central greenhouse area. In the 2nd Run, the terminal in the control room requires a completely different sequence of abstract symbols to release the lock. Inputting the correct pattern allows players to access the ladder leading down to the lounge and drug testing facilities.

The specific combination resembles a specialized series of pillars and geometric shapes that differs significantly from Leon or Claire's initial campaign. Memorizing this pattern prevents you from having to repeatedly dodge the aggressive Ivy zombies while searching for clues in the surrounding rooms. Once entered successfully, the path to the lower laboratory infrastructure becomes immediately accessible.

Unlocking the Drug Testing Lab Cabinet

The second essential terminal code is required to open the supply cabinet containing the crucial DNA storage capsule inside the Drug Testing Lab. Without this item, players cannot mix the herbicide required to clear away the overgrown vines blocking the primary exit route. The terminal interface uses the same alien symbol keyboard found near the greenhouse windows.

For the B Scenario playthrough, the sequence shifts to a brand new combination that can originally be found etched on a specific trophy item. Finding this trophy requires exploring the dark corridors of the lower level while managing your limited ammunition supplies. Entering this code opens the containment unit so you can secure the necessary empty cartridge for the next step.

Optimizing the Dispersal Cartridge Solution

Once you possess the capsule, you must visit the fluid synthesis machine to create the proper chemical balance for the herbicide. This puzzle challenges players to shift colored liquids between three test tubes of varying capacities to reach an exact target line. The manipulation sequence changes in the 2nd Run, requiring a new order of button presses to maximize efficiency.

Solving this puzzle quickly is vital because the laboratory environment continuously drains your health resources if you linger too long. A reliable method involves transferring contents strategically between the large and medium tubes before utilizing the small container to balance the final metrics. Completing this task grants you the fully synthesized mixture needed to neutralize the dangerous plant growth upstairs.